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A cinematic inspiration The invention was borne out of pedagogical necessity–to teach evolution in a visually captivating way to students in a graduate course at HMS. The researchers adapted an idea from–of all places–Hollywood. Senior study investigator Roy Kishony, of HMS and Technion, had seen a digital billboard advertising the 2011 film Contagion, a grim narrative about a deadly viral pandemic. The marketing tool was built using a giant lab dish to show hordes of painted, glowing microbes creeping slowly across a dark backdrop to spell out the title of the movie. “This project was fun and joyful throughout,” Kishony said. “Seeing the bacteria spread for the first time was a thrill. Our MEGA-plate takes complex, often obscure, concepts in evolution, such as mutation selection, lineages, parallel evolution and clonal interference, and provides a visual seeing-is-believing demonstration of these otherwise vague ideas. It’s also a powerful illustration of how easy it is for bacteria to become resistant to antibiotics.” Co-investigator Tami Lieberman says the images spark the curiosity of lay and professional viewers alike. “This is a stunning demonstration of how quickly microbes evolve,” said Lieberman, who was a graduate student in the Kishony lab at the time of the research and is now a postdoctoral research fellow at MIT. “When shown the video, evolutionary biologists immediately recognize concepts they’ve thought about in the abstract, while nonspecialists immediately begin to ask really good questions.” Bacteria on the move Beyond providing a telegenic way to show evolution, the device yielded some key insights about the behavior of bacteria exposed to increasing doses of a drug.

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